Care or practice bundles are a set of evidence-based, patient-focused practices or interventions (generally three to five) that aim to improve patient outcomes when done collectively and reliably. They can also be a tool to guide the delivery of a specific aspect of a patient care where the aim is to improve the care process and patient outcomes in a structured manner or sequence, with the expectation that the impact will be larger than single interventions alone (427). The GDG members acknowledged that there is no current consensus on which core interventions are essential for a CVC practice bundle and more data are needed to determine which components of the bundle are essential in reducing CLABSI. Bundles are most effective when implemented in an environment with an established patient safety culture and their success depends on adherence to each specific measure.

• The GDG emphasized the importance of prioritizing resources and tasks at the local level, considering other competing needs within the health care facility. This prioritization can help determine which components should be included in the CVC care bundle.
• The GDG also observed that having a bundle in place may not be enough on its own. Additional factors should also be considered, such as ensuring sufficient personnel for its implementation.